[An analysis of DNA reparative synthesis in the lymphocytes of bronchial asthma patients].

Spontaneous and UV-stimulated unschedule syntheses (US) of DNA in the peripheral blood lymphocytes and HLA antigens were investigated for asthmatic patients. The index of stimulation (IS) of DNA repair was determined as the ratio of the values of UV-stimulated US to spontaneous US. In the patients, a significant elevation of the intensity of spontaneous DNA US and the decrease in IS values were revealed as compared with the healthy controls.

[The significance of immunogenetic body characteristics in the formation and development of bronchial asthma].

The antigenic composition of tissues was shown to be of importance in the formation of bronchial asthma on the basis of the clinicoimmunological data with regard to histocompatibility antigens in 235 patients suffering from bronchial asthma and preasthma. Well-defined correlations were established between the development of bronchial asthma with carriership of antigens A2, B13, B21 and B35, between the disease pattern and nature of its course and antigens B7, B12, B27, B35, B40 together with their combinations. Possible variants of the relationship between the body traits and certain mechanisms by which bronchial asthma develops are under discussion.

[The cytogenetic action of antilymphocyte globulin on the lymphocytes of bronchial asthma patients].

Chromosomal aberration levels and frequencies of sister chromatid exchanges (SCE) in peripheral blood lymphocytes were investigated for patients with bronchial asthma treated with antilymphocyte globulin (ALG). The significant elevation of chromosomal aberration levels and SCE frequencies were revealed as compared to the healthy controls. The significant differences in chromosomal aberration levels were not observed before and after the courses of ALG therapy.