Case report: Clinical and immunohistochemical manifestations of suspected Sjogren's disease in a dog.

Sjogren's disease, well-described in people, is rarely identified in veterinary species. In people, Sjogren's disease is one of the most common systemic autoimmune disorders with an incidence of 0.5% in the female population.

Mitoclone2: an R package for elucidating clonal structure in single-cell RNA-sequencing data using mitochondrial variants.

Clonal cell population dynamics play a critical role in both disease and development. Due to high mitochondrial mutation rates under both healthy and diseased conditions, mitochondrial genomic variability is a particularly useful resource in facilitating the identification of clonal population structure. Here we present mitoClone2, an all-inclusive R package allowing for the identification of clonal populations through integration of mitochondrial heteroplasmic variants discovered from single-cell sequencing experiments.

Prospectively accelerated dynamic speech magnetic resonance imaging at 3 T using a self-navigated spiral-based manifold regularized scheme.

This work develops and evaluates a self-navigated variable density spiral (VDS)-based manifold regularization scheme to prospectively improve dynamic speech magnetic resonance imaging (MRI) at 3 T. Short readout duration spirals (1.3-ms long) were used to minimize sensitivity to off-resonance.

A topological deep learning framework for neural spike decoding.

The brain's spatial orientation system uses different neuron ensembles to aid in environment-based navigation. Two of the ways brains encode spatial information are through head direction cells and grid cells. Brains use head direction cells to determine orientation, whereas grid cells consist of layers of decked neurons that overlay to provide environment-based navigation.

The relation of velopharyngeal coupling area and vocal tract scaling to identification of stop-nasal cognates.

The purpose of this study was to determine whether the threshold of velopharyngeal (VP) coupling area at which listeners switch from identifying a consonant as a stop to a nasal in North American English was different for speech produced by a model based on an adult male, an adult female, and a 4-year-old child. V1CV2 stimuli were generated with a speech production model that encodes phonetic segments as relative acoustic targets imposed on an underlying vocal tract and laryngeal structure that can be scaled according to sex and age. Each V1CV2 was synthesized with a set of VP coupling functions whose maximum area ranged from 0 to 0.