[The highly specific and sensitive analysis of repertoire of serum antibodies using peptide microchips in patients with diagnosis of breast cancer.].

Nowadays, the search for new biomarkers of cancer is actual for early diagnostic. The antibodies against antigens associated with tumors arouse an interest as an alternative to the present biomarkers. The alteration of quantity and specificity of antibodies in blood serum indicates processes occurring in the organism, including development of oncologic diseases.

[Rat brain reactions to acute brain stem lesion on dynamics of parameters of cerebral electric activity].

Despite an old history of a question, adaptive brain reactions that develop after an acute brainstem lesion have not been adequately investigated. With the aim to study the central mechanisms of compensation/decompensation and to specify the character of involvement of orbitofrontal cortex and hippocampus into these processes the spatiotemporal organization of brain electric activity was analyzed in 8 rats before and after electrolytic brainstem lesion at the level of the lateral vestibular nucleus Deiters (VND). The electric activity was recorded from symmetric frontal and somatosensory cortical areas, hippocampal areas CA1, and intact VND.

Long-term ongoing reorganizations of the processes of analysis of kinesthetic afferentation at the level of cat motor cortex neurons after damage to the ventrolateral nucleus of the thalamus.

The changes in the functional characteristics of neurons of field 4 of the motor cortex (MC) of cats before and at various times (from a week up to five months) following an ipsilateral lesion of the ventrolateral nucleus of the thalamus were investigated in semichronic experiments. The reactions of the cells to tactile stimulation of the forelimb and its passive movement at the wrist at an average speed of 170 degrees/sec were studied. It was demonstrated that a correlation between the impulse activity at speed maxima and the acceleration of monoarticular movement is characteristic for a number of cells of the MC of the intact brain.

[Long-term rearrangements of the processing of kinesthetic afferentation at the neuronal level of the cat motor cortex after damage to the ventrolateral thalamic nucleus].

Single-unit recordings from motor cortex (area 4) were obtained in cats and under semichronic experimental conditions before and within various periods (from a week to five months) after the lesion in thalamic nucleus ventralis lateralis (n. VL). Neuronal responses to tactile stimulation of the contralateral forelimb and its passive movement in the wrist joint with the mean speed 170 degrees/s were studied.