Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases.

NMDAR antagonists, such as memantine and ketamine, have shown efficacy in treating neurodegenerative diseases and major depression. The mechanism by which these drugs correct the aforementioned diseases is still unknown. Our study reveals that these antagonists significantly enhance 20S proteasome activity, crucial for degrading intrinsically disordered, oxidatively damaged, or misfolded proteins, factors pivotal in neurodegenerative diseases like Alzheimer's and Parkinson's.

Identification and comparison of -glycome profiles from common dietary protein sources.

The glycomes of bovine whey, egg white, pea, and soy protein isolates are described here. -glycans from four protein isolates were analyzed by HILIC high performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (HILIC-FLD-QTOF-MS/MS). In total, 33 glycans from bovine whey and egg white and 10 -glycans from soy and pea glycoproteins were identified.

Credibility-based knowledge graph embedding for identifying social brand advocates.

Brand advocates, characterized by their enthusiasm for promoting a brand without incentives, play a crucial role in driving positive word-of-mouth (WOM) and influencing potential customers. However, there is a notable lack of intelligent systems capable of accurately identifying online advocates based on their social interactions with brands. Knowledge Graphs (KGs) offer structured and factual representations of human knowledge, providing a potential solution to gain holistic insights into customer preferences and interactions with a brand.

Comparative Immunohistochemical Analysis of Craniopharyngioma and Ameloblastoma: Insights into Odontogenic Differentiation.

Background And Objectives: Histopathological similarities between craniopharyngioma (CP) and ameloblastoma (AB) have long been recognized, particularly the shared features of palisading columnar epithelium and stellate reticulum-like areas. This study aimed to investigate potential odontogenic differentiation in CP akin to AB using immunohistochemical odontogenic markers.

Methods: We analyzed AMELX, ODAM, and CK19 expression in 44 cases (20 CP and 24 AB).

Arabic Wikipedia users' personalized behavior analysis considering gender gap.

Introduction: As many web platforms adopt collaborative content editing models, the gender gap is addressed as one of the chief concerns in using technology to restrict content editing by one gender.

Objective: This study aims to analyze the Arabic Wikipedia, the largest collaborative content editing platform on the Arabic web, in terms of gender behavior and differences in user activities.

Methods: This study is the first to address the gender gap in Arabic Wikipedia, characterize users' gender through their behavior, and then address changes in characteristics over the past five years.