Publications by authors named "B M Rodgers"
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease is a major cause of chronic liver issues globally, and regular physical activity is recommended as an effective treatment.
- A 16-week randomized controlled trial with 45 adults will explore the effects of different exercise doses on various health outcomes related to this liver condition.
- The study aims to clarify how exercise influences liver fat (measured by MRI), inflammation, and overall quality of life, making it the first to compare varying exercise intensities in this context.
Article Synopsis
- The study focuses on laparoscopic pyloromyotomy (LP) for treating infantile hypertrophic pyloric stenosis (IHPS) in infants, aiming to examine the use of preoperative antibiotics and its correlation with postoperative surgical site infection (SSI) rates.
- An analysis of 227 patients revealed that only 1.3% developed an SSI within 30 days post-surgery, with no significant difference in SSI rates between those who received antibiotics and those who did not.
- The findings suggest that while LP has low infection rates, there is considerable variability in antibiotic usage among surgeons, highlighting the need for standardized guidelines to reduce unnecessary antibiotic use.
DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance by DNMT1, or if it has important additional functions. Using degron alleles, we show that UHRF1 depletion causes a much greater loss of DNA methylation than DNMT1 depletion.
View Article and Find Full Text PDFBreast cancer is the most prevalent type of cancer in women worldwide. Within breast tumors, the basal-like subtype has the worst prognosis, prompting the need for new tools to understand, detect, and treat these tumors. Certain germline-restricted genes show aberrant expression in tumors and are known as Cancer/Testis genes; their misexpression has diagnostic and therapeutic applications.
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