[Problem of drug-resistant tuberculosis and the way of its solution].

Drug-resistant tuberculosis in the Ukraine and in other countries as well is a great important problem. The presence of drug-resistant Mycobacteria worsens clinical and bacteriological responses to therapy, prolongs hospital stay, and increases costs. The novel derivative of rifampicin, rifabutin, produced by Pharmacia & Upjohn under the trade name Mycobutin is more effective and safe than rifampicin.

[The diagnosis of allergy to industrial chemical compounds using a method of immunothermistometry].

An evaluation was done in those individuals engaged in the production of detergents, enzymic preparations, electron tubes and measuring instrumentation, using allergologic, laboratory methods and immunothermistometry of blood with allergens obtained from industrial chemical compounds. Feasibility is demonstrated of employing in the diagnosis of chemical allergy the immunothermistometry technique which was found to be superior to the known laboratory immunologic tests.

[Influence of enzyme industry products on the human immune system].

Enzyme industry products had significant allergo- and immunogenic effects on human body, manifesting by allergic dermatitis and respiratory forms of allergy. Most negative effects on immune system had alkaline protease 1 and 2, salizymelipase, neutral protease and protease C. Problems of diagnosis and modernizations of in-plant conditions were discussed.

[Drug allergy in pulmonary tuberculosis patients].

The authors studied the frequency, etiological structure of drug allergy in 7381 patients with pulmonary tuberculosis within the period from 1980 through 1989. Determined were the factors furthering the more frequent formation of drug allergy. Studied were the prevailing clinical manifestations of drug allergy in patients with pulmonary tuberculosis as well as the types of drug-related allergic reactions according to the Jelal-Coombs classification.