Publications by authors named "B M Peault"
Human blood vessel walls show concentric layers, with the outermost tunica adventitia harboring mesenchymal progenitor cells. These progenitor cells maintain vessel homeostasis and provide a robust cell source for cell-based therapies. However, human adventitial stem cell niche has not been studied in detail.
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- Scientists are working on using special types of stem cells called Long-term reconstituting haematopoietic stem cells (LT-HSCs) to help treat blood problems through transplants.
- One challenge is that LT-HSCs are hard to find and don’t live long in lab conditions, but researchers have made progress in keeping them alive using special support systems.
- They created a new game-changing environment using soft materials that help these LT-HSCs survive and even support gene editing, which could improve treatment for blood disorders!
Perivascular cells represent an in vivo counterpart of mesenchymal stromal/stem cells that populate the outer layer of blood vessels. Pericytes in capillaries and microvessels and adventitial cells of large arteries and veins give rise to stem/progenitor cells when isolated and cultured in vitro. These cells have been considered candidate cell types for cell therapy.
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