Publications by authors named "B M Mueller"
Background: Affective bias toward negativity is associated with depression and may represent a promising treatment target. Stimulating the dorsolateral prefrontal cortex (dlPFC) with deep Transcranial Magnetic Stimulation (dTMS) could lead to shifts in affective bias. The current study examined behavioral and neural correlates of affective bias in the context of dTMS in adolescents with treatment-resistant depression (TRD).
View Article and Find Full Text PDFImportance: Stereotactic body radiation therapy (SBRT) for spinal metastases improves symptomatic outcomes and local control compared to conventional radiotherapy. Treatment failure most often occurs within the epidural space, where dose is constrained by the risk of radiation myelitis (RM). Current constraints designed to prevent RM after spine SBRT are derived from limited data.
View Article and Find Full Text PDFBackground: Exposure with Response Prevention (ERP) is a first-line treatment for OCD, but even when combined with first-line medications it is insufficiently effective for approximately half of patients. Compulsivity in OCD is thought to arise from an imbalance of two distinct neural circuits associated with specific subregions of striatum. Targeted modulation of these circuits via key cortical nodes (dorsolateral prefrontal cortex [dlPFC] or presupplementary motor area [pSMA]) has the potential to improve ERP efficacy by decreasing compulsions during therapy.
View Article and Find Full Text PDFArticle Synopsis
- Migratory birds like the Gambel's white-crowned sparrow rely heavily on mitochondria for energy during their intense migration periods, which is energetically demanding.
- In a study comparing Gambel's sparrows with non-migratory Nuttall's sparrows, it was found that the migratory birds showed significantly more mitochondrial remodelling in their muscles across different stages of migration.
- The research indicates that this remodelling is particularly evident in the pectoralis muscle, which is crucial for flight, demonstrating an adaptive response that helps migratory birds meet their increased energy requirements.
Aim: To quantify regional subcortical brain volume anomalies in youth with fetal alcohol spectrum disorder (FASD), assess the relative sensitivity and specificity of abnormal volumes in FASD vs. a comparison group, and examine associations with cognitive function.
Method: Participants: 47 children with FASD and 39 typically-developing comparison participants, ages 8-17 years, who completed physical evaluations, cognitive and behavioral testing, and an MRI brain scan.