Evolutionary Changes in the Content of Dehydrogenase System Metabolites as a Mechanism of Adaptation to Cold in Higher Vertebrates.

It has been found that the optimal body balance control under the conditions of the adaptation to cold is mostly determined by the ratio of the blood concentrations of endogenous ethanol and acetaldehyde related to the activities of liver alcohol dehydrogenase and aldehyde dehydrogenase in the order of increasing level of adaptation: higher vertebrates unadapted to cold, including human → small animals adapted to cold → large animals adapted to cold native to the North → hibernators, regardless of the species specificity and the environment.

LICHENS' B-OLIGOSACCHARIDES IN THE CORRECTION OF METABOLIC DISORDERS IN TYPE 2 DIABETES MELLITUS.

Introduction: Lichens of the genus Cladonia are used as medicinal plants in folk medicine. Biologically active food supplement (BAFS) on the basis of lichens p. Cladonia was derived by mechanical-chemical biotechnology in the Educational-Research-Engineering Laboratory "Mechanical-Chemical Biotechnology" of the North-Eastern Federal University (NEFU).

Stabilization of Homeostasis in Rats during Cold Exposure with Ethanol.

The role of ethanol metabolism system in adaptation of laboratory animals to cold temperatures was shown. Cold stress (1-2°C) modeled in male Wistar rats over 7 weeks significantly modulated endogenous ethanol metabolism and led to reorganization of many physiological systems, which resulted in activation of metabolic processes. Under these conditions, endogenous ethanol was utilized as the most easily and fast metabolized energy substrate, due to which its blood concentration decreased and was replenished at the expense of exogenous ethanol.

[The evaluation of the endogenous intoxication level in the sterile phase of pancreonecrosis].

The study is based on the analysis of the conservative and surgical treatment of 123 patients with the "sterile phase" of pancreonecrosis, completed by the evaluation of biochemical indexes of the endogenous intoxication. The achieved results specify the important role of the independent inflammation predictors in a complex estimation of the severity prognosis and the complication possibility after the operative treatment of the acute destructive pancreatitis.