Publications by authors named "B M Hause"
High mortality in bobwhite quail chicks () (35%-85%) was reported from a grower flock in Iowa during July and August of 2022. Two diagnostic submissions of dead, 3-day-old quail chicks were received. Postmortem examination revealed multifocal, pinpoint, pale tan foci in the liver of all birds.
View Article and Find Full Text PDFUnlabelled: The deformed wing virus () (DWV) is a key driver of colony loss in the western honey bee (). Here, we demonstrate that orally delivered anti-DWV antibodies can act systemically to reduce DWV loads in naturally infected honey bees. Immunoglobulin Y (IgY) was produced in adult chickens against two DWV proteins, harvested from their eggs, and fed to bees in a sucrose solution.
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- The development of new anti-cancer drugs is hindered by challenges in identifying their mode of action (MoA), but a combination of metabolomics and machine learning has been used to predict MoAs for new drug candidates targeting prostate cancer cells.
- In a study of 38 drugs affecting cancer metabolism, distinct metabolic patterns enabled accurate predictions of MoAs, and these predictions were validated across other cancer types such as breast cancer and Ewing's sarcoma, albeit with some loss in prediction quality.
- This approach not only enhances understanding of drug effects on cellular processes, such as mitochondrial dysfunction, but also opens up new avenues for optimizing drug combinations to improve treatment outcomes.
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- Equine rotavirus species A genotypes G3P[12] and G14P[12] are major causes of foal diarrhea, impacting the equine industry economically and showing potential for zoonotic transmission to humans, as seen in past outbreaks of severe gastroenteritis in children.
- Traditional cell culture methods for isolating rotaviruses are ineffective for ERVA, but researchers successfully isolated both strains using engineered cell lines with reduced antiviral immunity, revealing genetic similarities and differences that affect their ability to invoke immune responses.
- The study highlights limited cross-neutralization between G3P[12] and G14P[12], which explains increased diarrhea outbreaks in foals despite immunity from vaccines targeting G3P[12], paving
Background: 'Candidatus Phytoplasma mali', the causal agent of apple proliferation disease, exerts influence on its host plant through various effector proteins, including SAP11 which interacts with different TEOSINTE BRANCHED1/ CYCLOIDEA/ PROLIFERATING CELL FACTOR 1 and 2 (TCP) transcription factors. This study examines the transcriptional response of the plant upon early expression of SAP11. For that purpose, leaves of Nicotiana occidentalis H.
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