Publications by authors named "B M Graf"
Article Synopsis
- Fluconazole-resistant Candida parapsilosis is a growing concern in healthcare settings, leading to outbreaks similar to those caused by Candida auris, with a notable outbreak documented in Berlin from late 2018 through 2022.
- A retrospective study employed whole-genome sequencing (WGS) to analyze samples from various healthcare facilities to track the spread and resistance patterns of this pathogen.
- The research aimed to create a reliable multi-locus sequence typing (MLST) system to better understand and monitor the outbreak, using patient records and genomic data to analyze transmission dynamics.
Adeno-associated viruses (AAV) are widely used viral vectors for in vivo gene therapy. The purification of AAV, particularly the separation of genome-containing from empty AAV capsids, is usually time-consuming and requires expensive equipment. In this study, we present a novel laboratory scale anion exchange flow-through polishing method designed to separate full and empty AAV.
View Article and Find Full Text PDFArticle Synopsis
- The significance of prehospital cervical spine immobilization in trauma patients is debated, especially due to potential negative effects like increased intracranial pressure, necessitating further research on the long-term use of rigid orthoses.
- A study was conducted comparing cervical spine mobility when using a vacuum mattress with and without a rigid orthosis during simulated emergency transport in an ambulance.
- Results showed statistically significant differences in biomechanical parameters, indicating that the use of a rigid orthosis may impact cervical spine movement during transport, but further investigation is needed to draw firm conclusions.
Background And Aims: During the coronavirus disease 2019 (COVID-19) pandemic a significant proportion of patients with severe acute respiratory distress syndrome (ARDS) due to COVID-19 infection developed secondary sclerosing cholangitis (SSC) as a hepatobiliary complication.
Methods: 17 patients were endoscopically diagnosed and treated with COVID-19 SSC from February 2020 until October 2022 at our center. We retrospectively reviewed and analyzed the data to define risk factors, establish endoscopic treatment options, and to estimate incidence and outcomes.