Complications after knee derotational osteotomies in patients with anterior knee pain and/or patellofemoral instability: a systematic review with meta-analysis.

Purpose: Investigate intra- and post-operative complications and revisions following distal femoral and/or high tibial derotational osteotomies to correct rotational malalignments of the lower limb in patients with anterior knee pain (AKP) and/or patellofemoral instability (PFI).

Methods: A literature search was conducted on PubMed, EMBASE and Web of Science (until 30 September 2023), including studies reporting complications, reinterventions and revisions following knee derotational osteotomies. Incidence rates were collected for each level of derotational osteotomy (distal femur, high tibia or double-level).

Inhibition of pneumococcal growth and biofilm formation by human isolates of and .

Unlabelled: In a world facing the unprecedented threat of antibiotic-resistant bacteria, targeted approaches to control colonization and prevent disease caused by common pathobionts offer a promising solution. (pneumococcus) is a leading cause of infections worldwide, affecting both children and adults despite available antimicrobials and vaccines. Colonization, which occurs in the form of a biofilm in the upper respiratory tract, is frequent and a prerequisite for disease and transmission.

The Importance of Studying Infectious and Parasitic Diseases of Wild Animals in the Amazon Biome with a Focus on One Health.

The Amazon Biome is home to an extraordinary diversity of wildlife, many of which are reservoirs or vectors for infectious and parasitic diseases that can impact not only the health of wild animals but also human and domestic animal populations. This narrative review highlights the critical importance of studying infectious and parasitic diseases in wild animals within the Amazon, particularly in the context of the One Health approach, which recognizes the interconnectedness of human, animal, and environmental health. This narrative review examines key pathogens, including viruses, bacteria, and parasites, that pose significant risks to wildlife conservation and public health.

Distinct metabolic profiles of circulating plasmacytoid dendritic cells in systemic sclerosis patients stratified by clinical phenotypes.

Background: Plasmacytoid dendritic cells (pDCs) play a key role in systemic sclerosis (SSc) pathophysiology. However, despite the recognised importance of metabolic reprogramming for pDC function, their metabolic profile in SSc remains to be elucidated. Thus, our study aimed to explore the metabolic profile of pDCs in SSc and their potential contribution to the disease.