Publications by authors named "B M Elicker"
Article Synopsis
- * Researchers conducted a cross-sectional analysis involving 489 SSc-ILD patients, classifying their HRCTs to determine the presence of UIP.
- * Results showed that while MUC5B was not linked to UIP patterns, the FAM13A gene was associated with an increased likelihood of definite UIP in these patients, suggesting different genetic influences compared to idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis-related ILD.
By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) in a subset of metaplastic MUC5AC mucus secretory cells, and that ITLN-1 protein is a secreted component of IL-13-induced mucus.
View Article and Find Full Text PDFThe American College of Radiology created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019 and revised size thresholds for nonsolid nodules, added classification criteria for perifissural nodules, and allowed for short-interval follow-up of rapidly enlarging nodules that may be infectious in etiology.
View Article and Find Full Text PDFArticle Synopsis
- This study analyzed CT lung scans from 57 asthma patients to understand mucus plug characteristics, focusing on their size, location in the airways, and behavior over three years.
- Mucus plugs were categorized as "stubby" (≤12 mm) or "stringy" (>12 mm), with a significant proportion of airflow obstruction linked to the longer plugs found mostly in airway generations 6-9.
- The research found persistent mucus plugs in proximal regions of the airway, indicating that these plugs impact airflow and may be effectively targeted with inhaled treatments or bronchoscopy.
The ACR created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019 and revised size thresholds for nonsolid nodules, added classification criteria for perifissural nodules, and allowed for short-interval follow-up of rapidly enlarging nodules that may be infectious in etiology.
View Article and Find Full Text PDF