[Activity of enzymes participating in xenobiotic metabolism and the condition of microsomal membranes of rat liver in vitamin K deficiency].

Alimentary deficiency or vitamin K (vitamin K-poor diet) as well as the vitamin deficiency resulting from sinkumar administration are accompanied by a decreased activity of microsomal demethylases, hydroxylase, NADH- and nNADPH-reductases of dichlorophenolindophenol and neotrazolium. The activity of cytosolic enzymes (only glutathione-S-transferases, aryl- and allyl esterases) is diminished in a lesser degree. Vitamin K deficiency does not significantly interfere with the effect of the xenobiotic metabolism enzyme inducer (phenobarbital) or the cytochrome P-450 inhibitor (cobalt chloride).

[Modification of the pharmacokinetics of ortophen and its analgesic activity by inducers and inhibitors of xenobiotic metabolism enzymes and thiamine diphosphate].

Phenobarbital administered in a dose of 70 mg/kg intraperitoneally (once a day for 4 days) was shown to accelerate ortophen elimination from blood of rats and to decrease its analgesic activity. Administration of cimetidine (100 mg/kg, intragastrically once a day for 5 days), cobalt chloride (10 mg/kg, subcutaneously twice) and thiamine diphosphate (10 mg/kg, intraperitoneally once a day for a week) was found to slow down elimination of ortophen from blood and to enhance its analgesic effect. Cimetidine slows down ortophen elimination from blood of the patients.

[Glutathione and ascorbic acid metabolism and antioxidant enzyme activity in the tissues of vitamin E-deficient rats].

In has been shown in the experiments on male rats that alimentary vitamin E deficit causes the decrease of reduced glutathione and ascorbic acid concentration in the liver and lungs and that of glutathione-S-transferase, glutathione reductase in the liver and lungs, catalase in the liver and glutathione peroxidase in the heart activity, but increases the amount of glutathione disulfide in the liver and lungs and superoxide dismutase and gamma-glutamyltransferase activity in the liver. The data obtained show the selective character of reaction participants of the antioxidant system of rats' organism to the deficit of one of the antioxidant factors--vitamin E and also testify to complex interrelation between separate members of this system.