Use of alternatives to animal testing for Environmental Safety Assessment (ESA): Report from the 2023 EPAA partners' forum.

Environmental Safety Assessments (ESA) are mandatory for several regulatory purposes and are an important component of stewardship/sustainability initiatives. Fish testing is used for assessing chemical toxicity and bioaccumulation potential; amphibians are included in some jurisdictions and their use is increasing to assess endocrine disruption. Alternative methods are becoming more available, covering the principles of the 3Rs (i.

The QUIC-SP: A Spanish language tool assessing unpredictability in early life is linked to physical and mental health.

Accumulating evidence indicates that unpredictable signals in early life represent a unique form of adverse childhood experiences (ACEs) associated with disrupted neurodevelopmental trajectories in children and adolescents. The Questionnaire of Unpredictability in Childhood (QUIC) was developed to assess early life unpredictability [1], encompassing social, emotional, and physical unpredictability in a child's environment, and has been validated in three independent cohorts. However, the importance of identifying ACEs in diverse populations, including non-English speaking groups, necessitates translation of the QUIC.

Repair bond strength of resin composite to CAD/CAM glass-ceramic: Influence of cleaning methods, surface treatments, and aging.

Objective: To evaluate the influence of different cleaning methods, surface treatments, and aging on the repair bond strength to a CAD/CAM glass-ceramic.

Materials And Methods: Forty-eight lithium disilicate CAD/CAM ceramic blocks were fabricated, sintered, and embedded in acrylic resin. After contamination with human saliva, they were divided according to the factors "Cleaning method" (Control-water/air spray, Air-particle abrasion with AlO, Ivoclean cleaning paste), "Surface treatment" (5 % Hydrofluoric acid-HF + Silane, Monobond Etch & Prime-MEP), and "Aging" (thermocycling, no thermocycling).

Household transmission of SARS-CoV-2 in five US jurisdictions: Comparison of Delta and Omicron variants.

Households are a significant source of SARS-CoV-2 transmission, even during periods of low community-level spread. Comparing household transmission rates by SARS-CoV-2 variant may provide relevant information about current risks and prevention strategies. This investigation aimed to estimate differences in household transmission risk comparing the SARS-CoV-2 Delta and Omicron variants using data from contact tracing and interviews conducted from November 2021 through February 2022 in five U.

Resistance training protects the hippocampus and precuneus against atrophy and benefits white matter integrity in older adults with mild cognitive impairment.

Mild cognitive impairment (MCI) refers to cognitive alterations with preservation of functionality. Individuals with this diagnosis have a higher risk of developing dementia. Non-pharmacological interventions, such as physical exercise, are beneficial for the cognition of this population.