An In Vivo Assessment of Different Mesenchymal Stromal Cell Tissue Types and Their Differentiation State on a Shape Memory Polymer Scaffold for Bone Regeneration.

A combined biomaterial and cell-based solution to heal critical size bone defects in the craniomaxillofacial area is a promising alternative therapeutic option to improve upon autografting, the current gold standard. A shape memory polymer (SMP) scaffold, composed of biodegradable poly(ε-caprolactone) and coated with bioactive polydopamine, was evaluated with mesenchymal stromal cells (MSCs) derived from adipose (ADSC), bone marrow (BMSC), or umbilical cord (UCSC) tissue in their undifferentiated state or pre-differentiated toward osteoblasts for bone healing in a rat calvarial defect model. Pre-differentiating ADSCs and UCSCs resulted in higher new bone volume fraction (15.

Evaluating Thera-101 as a Low-Volume Resuscitation Fluid in a Model of Polytrauma.

Traumatic brain injury (TBI) and hemorrhage remain challenging to treat in austere conditions. Developing a therapeutic to mitigate the associated pathophysiology is critical to meet this treatment gap, especially as these injuries and associated high mortality are possibly preventable. Here, Thera-101 (T-101) was evaluated as low-volume resuscitative fluid in a rat model of TBI and hemorrhage.

L1 Grammatical Gender Variation through the Representation in the Lexicon.

In most studies on gender processing, native speakers of the same language are treated as a homogeneous group. The current study investigates to what extent an ongoing change in the gender system of Norwegian (a development from three to two genders, involving the loss of feminine) may be reflected in processing. We carried out a gender decision task in which speakers were presented with 32 nouns of each gender (masculine, feminine, neuter) and asked to select the corresponding indefinite article.

Comparative evaluation of mesenchymal stromal cell growth and osteogenic differentiation on a shape memory polymer scaffold.

Trauma-induced, critical-size bone defects pose a clinical challenge to heal. Albeit autografts are the standard-of-care, they are limited by their inability to be shaped to various defect geometries and often incur donor site complications. Herein, the combination of a "self-fitting" shape memory polymer (SMP) scaffold and seeded mesenchymal stromal cells (MSCs) was investigated as an alternative.

Language Separation in Bidialectal Speakers: Evidence From Eye Tracking.

The aim of this study was to find out how people process the dialectal variation encountered in the daily linguistic input. We conducted an eye tracking study (Visual Word Paradigm) that targeted the online processing of grammatical gender markers. Three different groups of Norwegian speakers took part in the experiment: one group of students from the capital Oslo, and two groups of dialect speakers of the Sogn dialect of Western Norway.