Publications by authors named "B Lloveras"
Article Synopsis
- Mixed carcinomas, which represent about 10% of penile carcinomas, consist of multiple distinct histological subtypes, categorized by the World Health Organization (WHO) into two groups based on their HPV association.
- The study aimed to detect HPV genotypes in these mixed tumors, revealing a higher HPV positivity rate (46%) in carcinomas with warty/basaloid features compared to a low rate (7%) in non-warty/basaloid types.
- HPV16 was the most commonly identified genotype (65%), and the presence of HPV-associated morphology above 20% in mixed tumors is critical for classification as HPV-associated, in accordance with WHO guidelines.
Many scientific societies have issued guidelines to introduce population-based cervical cancer screening with HPV testing. The Vitro HPV Screening assay is a fully automatic multiplex real-time PCR test targeting the L1 GP5+/GP6+ region of HPV genome. The assay detects 14 high risk (HR) HPV genotypes, identifying individual HPV16 and HPV18 genotypes, and the HPV-positive samples for the other 12 HR HPV types are subsequently genotyped with the HPV Direct Flow Chip test.
View Article and Find Full Text PDFStromal tumor-infiltrating lymphocytes (sTILs) are a robust prognostic and predictive biomarker in triple-negative breast carcinoma. However, the sTIL compartment comprises different cell populations. The aim of the study is to characterize the distribution of T cells (CD3+ and CD8+), B cells, and plasma cells and explore their association with outcome in the surgical specimen of 62 patients.
View Article and Find Full Text PDFArticle Synopsis
- Stromal tumour infiltrating lymphocytes (sTIL) in breast cancer are associated with improved outcomes and responses to treatment, particularly in triple-negative and HER2-positive types.
- A study developed a deep-learning model called smsTIL to analyze different cell types in breast cancer tissue images, focusing on sTILs and their correlation with patient outcomes.
- The analysis showed a strong agreement between visual and semi-automated scoring of sTIL and indicated that higher smsTIL levels are linked to better overall survival, establishing smsTIL as an independent prognostic factor for patients with triple-negative breast cancer.
Article Synopsis
- HPV is found in 30-50% of invasive penile cancers, often linked to specific cell types like basaloid and warty carcinomas, indicating diversity in genetic behavior.
- A study of 177 HPV-positive cases revealed 19 genotypes, with a high prevalence of high-risk types (96%) and HPV16 being the most common.
- The findings suggest that current HPV vaccinations would cover 93% of cases, with distinct patterns in genotype distribution—HPV16 being more frequent in basaloid cancers compared to warty forms, highlighting their unique characteristics.