Tubulointerstitial Nephritis With Uveitis (TINU): A Syndrome Rheumatologists Should Recognize: A Case Report and Review of the Literature.

Patients with uveitis such as the patient whose case is reported here are often referred to rheumatologists for investigation of possible underlying systemic diseases. This patient presented with decreased vision, photophobia, weight loss, and fevers and was found to have uveitis, elevated creatinine, and interstitial nephritis. This raised consideration of a variety of systemic diseases before she was determined to have the tubulointerstitial nephritis with uveitis (TINU) syndrome.

Age and sex-related difference in levels of nerve growth factor in organs of Balb/c mice.

The presence of nerve growth factor (NGF) is reported in salivary glands of mice and sex organs of various male animals. NGF level is reported to be higher in salivary glands of male mice in comparison to female. This investigation reports the presence of NGF in major organs of Balb/c mice showing quantitative differences in NGF according to sex and age.

Assay of specific antibodies produced in organs of mice immunized with nerve growth factor.

Immunization of mice with nerve growth factor (NGF) leads to the production of antibodies, which can be assayed, from the serum. Currently, it is considered that the spleen of an immunized animal is predominantly involved in the production of antibodies. Therefore, spleen cells of the immunized animal are used to fuse with the respective species of myeloma cells to create in vitro immortalized antibodies secreting hybridomas.

Restoration of nerve growth factor in organs of mice injected with cobra venom followed by specific treatment and reversal period.

Research from this laboratory reported the decreased levels of endogenously present nerve growth factor (NGF) in organs of mice as a consequence of sub-lethal injection of Naja kaouthia venom. This research reports that the decreased levels of NGF in organs of mice were prevented by (1) specific treatment and (2) restored to normal by a prolonged period. Adult female Balb/c mice were injected intramuscularly (IM) with a sub-lethal dose of cobra venom.