Publications by authors named "B Lippitz"
Background: Gamma Knife radiosurgery (GKRS) is a well-established treatment for residual or growing pituitary adenomas (PAs) post-partial resection. However, some PAs grow even after initial GKRS, for which the efficacy of repeat GKRS is unclear. The primary objective of this study was to determine long-term progression-free survival (PFS) following repeated GKRS in patients with PA.
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- Pituitary adenomas often lead to the need for Gamma Knife radiosurgery (GKRS) after incomplete removal or recurrence, and this study aims to assess its long-term effectiveness.
- In a cohort study of 147 patients who underwent GKRS between 1999 and 2020, the researchers evaluated progression-free survival (PFS) over an average follow-up of 8.1 years, finding a 5-year PFS of 86% and a 10-year PFS of 68%.
- Results indicated that somatotrophic adenomas had lower progression risks, but 32% of patients experienced adverse radiation events, mainly hypopituitarism, highlighting the need to weigh outcomes against potential side effects.
In May 1968, Lars Leksell and Erik-Olof Backlund achieved a pioneering breakthrough by performing the first Gamma Knife radiosurgery (GKRS) on a craniopharyngioma (CP). Today, more than 50 years later, this patient remains under continuous monitoring, providing the longest documented follow-up of a GKRS-treated CP. This case report provides a complete record of the patient's preoperative presentation, surgical assessment, GKRS, and an extensive long-term follow-up with multiple interventions.
View Article and Find Full Text PDFCavernous sinus meningiomas (CSMs) remain a surgical challenge due to the intimate involvement of their contained nerves and blood vessels. Stereotactic radiosurgery (SRS) is a safe and effective minimally invasive alternative for the treatment of small- to medium-sized CSMs. Objective: To assess the medium- to long-term outcomes of SRS for CSMs with respect to tumour growth, prevention of further neurological deterioration and improvement of existing neurological deficits.
View Article and Find Full Text PDFTen-year follow-up after Gamma Knife radiosurgery of meningioma and review of the literature.
Acta Neurochir (Wien)
September 2020
Objectives: With regard to the generally slow growth of meningioma, it is essential to analyse clinical treatment results in a long-term perspective. The purpose of the present analysis is to provide clinical data after Gamma Knife radiosurgery of meningioma in a 10-year perspective together with a review of the current literature.
Methods: The current study is a retrospective analysis of 86 consecutive Swedish patients with meningiomas treated using Gamma Knife radiosurgery at the Karolinska Hospital Stockholm between March 1991 and May 2001.