Publications by authors named "B Linhares"
Article Synopsis
- * The study, called KOMET-001, was conducted in multiple countries and involved dose-escalation and validation phases, with patients in specific molecular subtypes receiving varying doses of ziftomenib over 28-day cycles.
- * Results indicated that 83 patients were treated with ziftomenib from September 2019 to August 2022, and the findings are crucial for determining the drug's safety and effectiveness for future phases of clinical testing.
Type I melanoma antigen (MAGE) family members are detected in numerous tumor types, and expression is correlated with poor prognosis, high tumor grade, and increased metastasis. Type I MAGE proteins are typically restricted to reproductive tissues, but expression can recur during tumorigenesis. Several biochemical functions have been elucidated for them, and notably, MAGEs regulate proteostasis by serving as substrate recognition modules for E3 ligase complexes.
View Article and Find Full Text PDFMorphologically similar species that occupy resource-limited environments tend to differ in their ecological traits in order to coexist, which may result in differential exposure to environmental threats. For instance, partitioning of feeding resources may influence contaminant exposure and bioaccumulation in marine predators through different diets or foraging habitats. Here, we sampled three tropical seabird species breeding in sympatry in the southwestern Atlantic Ocean for blood and feather trace element concentrations (As, Hg, Cd, Pb), and assessed their foraging ecology with bio-logging (GPS tracks and time-depth recorders), analysis of regurgitated prey, and carbon and nitrogen stable isotope mixing models.
View Article and Find Full Text PDFBackground: Chemotherapy associated with breast cancer often induces cardiotoxicity, which compromises patients' health and quality of life.
Objective: To verify the effect of physical exercise on chemotherapy-induced cardiotoxicity, through the assessment of cardiac function in patients with breast cancer.
Methods: A systematic review and meta-analysis of clinical studies was conducted to evaluate the effectiveness of physical training in chemotherapy-induced cardiomyopathy in the PubMed, Web of Sciences and Scopus databases.
Background: Physical exercise can take on a multivariate form, including combat sports, specifically Taekwondo, a Korean sport characterized by strikes involving the hands and feet. This sport has been gaining popularity worldwide in recent years and is being practiced by diverse populations, including the older women.
Objective: This study aimed to investigate the effects of Taekwondo training on self-esteem and body image in older women with low bone mineral density (BMD).