Publications by authors named "B Lian"
Objective: The objective was to explore the characteristics of risk factors in children with cerebral palsy (CP), focusing on the effects of single risk factors and the number of risk factors on the classification, GMFCS level, and comorbidities of children with CP.
Methods: The medical records of children with CP hospitalized from 2015 to 2023 were reviewed. The effects of nine risk factors, such as hyperbilirubinemia, asphyxia, and HIE, on the classification, GMFCS level and comorbidities of children with CP were studied.
Autism spectrum disorders (ASDs) are characterized by deficits in social functioning, stereotyped patterns of behaviors, narrowed interests, and elevated anxiety. Certain ASD symptoms can persist, whereas others may improve throughout the lifespan, but the specific patterns of changes have not been clearly delineated. Using a valproic acid (VPA) rat model of ASD, the present study took a developmental approach and examined how autistic-like behaviors, including anxiety-like behavior, object obsession, and social functioning deficits, manifested differently in three critical periods representing preadolescent (postnatal day [PND] 25), adolescent (PND 45), and adulthood life stage (PND 75) in a sex-dependent manner.
View Article and Find Full Text PDFDue to the aggravation of atmospheric nitrogen and sulfur deposition and the unreasonable application of fertilizer, soil acidification is becoming increasingly serious. In heavy metal-contaminated soils, acidification not only seriously affects fertility but also the effectiveness and sustainability of conventional passivation remediation materials such as biochar. The application of calcium fertilizer may improve soil acidification, alleviate the aging of biochar materials in soil, and improve its remediation ability to composite polluted soil.
View Article and Find Full Text PDFArticle Synopsis
- Early life stress (ELS) is linked to adult mental disorders like PTSD, with varying effects based on gender and resilience factors.
- The study investigated emotional and cognitive behaviors in rats subjected to different durations of maternal separation (MS) and subsequent prolonged stress (SPS) in adulthood, noting anxiety, depression, and memory deficits.
- Key findings showed that maternal separation affects behaviors differently based on stress exposure duration, with observed changes in telomere length and protein expression that could relate to mechanisms of PTSD.
Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors.
Glob Med Genet
December 2024
Article Synopsis
- FGFR is a vital receptor involved in growth and tissue repair, but its gene mutations can lead to cancer by disrupting essential processes.
- Small molecule drugs and antibodies targeting FGFR mutations, like erdafitinib and pemigatinib, have shown clinical efficacy in treating certain cancer types.
- Effective screening methods for FGFR variants are essential for utilizing FGFR inhibitors in treatment, and a consensus has been developed to standardize diagnosis and treatment processes.