Publications by authors named "B Lesperance"

Article Synopsis
  • Therapeutic resistance is a major issue in metastatic colorectal cancer, prompting a study on genomic changes in liver metastases during treatment, which aimed to understand how these changes relate to patient outcomes.
  • Researchers collected liver metastatic samples before and after first-line therapy, analyzing their genomic profiles (specifically copy number aberrations) and correlating these profiles with patient survival rates.
  • The study discovered significant genomic alterations in metastatic lesions post-treatment, highlighting the need to analyze these lesions separately from primary tumors to identify potential treatment response biomarkers.
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Background: Providing care to cancer patients is associated with a substantial psychological and emotional load on oncology workers. The purpose of this project is to co-construct, implement and assess multidimensional intervention continuums that contribute to developing the resilience of interdisciplinary cancer care teams and thereby reduce the burden associated with mental health problems. The project is based on resources theories and theories of empowerment.

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In recent years, risk stratification has sparked interest as an innovative approach to disease screening and prevention. The approach effectively personalizes individual risk, opening the way to screening and prevention interventions that are adapted to subpopulations. The international perspective project, which is developing risk stratification for breast cancer, aims to support the integration of its screening approach into clinical practice through comprehensive tool-building.

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Introduction: The phase III MPACT trial in patients with metastatic pancreatic cancer (MPC) demonstrated superior efficacy of nab-paclitaxel (nab-P) plus gemcitabine (Gem) compared with Gem monotherapy, including the primary endpoint of overall survival (OS; median 8.7 vs. 6.

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