Publications by authors named "B Leone"
Bipolar disorder is a debilitating psychiatric condition characterized by recurrent episodes of mania and depression, affecting millions worldwide. While pharmacotherapy remains the cornerstone of treatment, a significant proportion of patients exhibit inadequate response or intolerable side effects to conventional medications. In recent years, neuromodulation techniques have emerged as promising adjunctive or alternative treatments for bipolar disorder.
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- Colorectal cancer (CRC) is linked to factors like obesity and inflammation, which may disrupt immune response by accumulating foam cells (FC) in tumors, potentially impacting cancer progression.*
- The study involved analyzing tumor samples from CRC patients to investigate the relationship between FC and immune cell dynamics, highlighting the presence of reduced CD8 T cells and increased regulatory T cells in tumors with high FC accumulation.*
- Results indicated that higher levels of FC are associated with worse outcomes, including lower disease-free survival rates in CRC, and in vitro experiments showed that FC suppress CD8 T cell activity through mechanisms involving TGF-β.*
Background: Management of mediastinal anastomotic leaks (MALs) after Ivor Lewis esophagectomy includes conservative, endoscopic, or surgical management. Endoscopic vacuum therapy (EVAC) is becoming a routine approach for MALs, although the outcomes have not been defined. This study aimed to describe the incidence, treatment, and outcomes of MALs in patients who underwent esophagectomy in 3 Italian high-volume centers that routinely use EVAC for MAL.
View Article and Find Full Text PDFIntroduction: Arteriovenous grafts (AVGs) serve as an alternative to native arteriovenous fistulas (AVFs) in the context of hemodialysis patient life planning. AVGs are more susceptible to developing outflow stenosis (due to intimal hyperplasia), thrombosis, and infections. However, an often overlooked contributor to AVG failure is cannulation damage.
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