Publications by authors named "B Legius"
Anaplastic thyroid carcinoma (ATC) is a deadly disease with very limited therapeutic options. There is an urgent need for new and efficacious drugs. Unfortunately accrual in clinical trials is problematic because of the rarity of the disease and often poor performance status at diagnosis.
View Article and Find Full Text PDFSevere intestinal ischemia during chemotherapy for small cell lung cancer.
Lung Cancer Manag
December 2017
Thromboembolic events (TEEs) are frequent in cancer patients, especially venous thrombosis. Arterial thrombosis is less frequent. Chemotherapy increases the risk of these TEEs.
View Article and Find Full Text PDFDriver oncogenes in Sub-Saharan African patients with non-small cell lung cancer.
Lung Cancer (Auckl)
November 2016
Article Synopsis
- Non-small cell lung cancer can have specific driver oncogenes like EGFR and ALK that could be targeted for therapy, with their prevalence varying by race, smoking habits, and gender.
- Most research on these oncogenes has focused on Caucasian and Asian populations, with little to no existing data on Sub-Saharan African patients where smoking is less prevalent.
- In a small case study of six Sub-Saharan African patients with advanced lung adenocarcinoma, a significant number had EGFR mutations (3/6) or ALK rearrangement (1/6), suggesting that the lower smoking rates in this group may be linked to a higher prevalence of these driver mutations.
Tuberculosis is still an important disease in Belgium, mainly in big agglomerations. For this reason, knowledge of this entity by a general practitioner is very important. Genetic tests able to identify the species of Mycobacterium tuberculosis have been developed in recent years, but also identification of resistance to 1st and 2nd line treatment through genetic methods has been developed.
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