Publications by authors named "B Lebe"
The Relationship of PRAME Expression with Clinicopathologic Parameters and Immunologic Markers in Melanomas: In Silico Analysis.
Appl Immunohistochem Mol Morphol
January 2025
PRAME is a cancer testis antigen whose expression is limited in normal tissues but is increased in cancers. Although there are studies revealing its oncogenic and immunogenic role, the relationship between PRAME expression and immunity in melanomas is not very clear. We aimed to reveal the relationship between PRAME expression and clinicopathologic parameters, immunologic markers, survival in melanomas.
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- A 50-year-old male with extensive eye condition was diagnosed with presumed xeroderma pigmentosum (XP) and grade 2 foveal hypoplasia after ophthalmologic and dermatology evaluations.
- Optical coherence tomography confirmed the foveal hypoplasia, and the patient underwent genetic testing due to the rarity of these two conditions occurring together.
- The genetic testing revealed mutations in several genes, particularly noting the link of the LYST gene to foveal hypoplasia, contributing to the understanding of this unusual case.
A 78-year-old man with a history of lung cancer, chemotherapy, radiotherapy, and coronavirus disease 2019 infection experienced visual deterioration of two-weeks’ duration in his right eye. There was multifocal, yellowish-white retinitis foci, vascular engorgement, and scattered intraretinal hemorrhages extending from posterior pole to retinal periphery in the right eye, whereas the left eye was normal. Intravitreal vancomycin, ceftazidime, clindamycin, and dexamethasone were given for endogenous endophthalmitis initially.
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- The study aims to enhance the management of melanocytic nevi with peripheral globules by analyzing dysplasia grades based on World Health Organization (WHO) criteria.
- Researchers classified 66 lesions from 56 patients, finding that 9.1% were melanomas, 39.4% high-grade dysplastic nevi, and 50% low-grade dysplastic nevi, with age and specific lesion characteristics linked to higher risks of severe dysplasia.
- The findings suggest that factors like age, irregular globule shape, and color diversity can help determine excision decisions, particularly advocating for excision of lesions in patients aged 60 and above due to increased melanoma risk.
Embedded Episcleral Foreign Body Mimicking Nodular Anterior Scleritis.
Turk J Ophthalmol
February 2024
A 56-year-old man was referred to our clinic for unilateral nodular scleritis unresponsive to systemic corticosteroids. A localized, nodular hyperemia on the nasal bulbar conjunctiva surrounding a central cyst-like lesion together with vascular engorgement was observed on slit-lamp examination of the left eye. No abnormal fundoscopic findings were noted.
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