Publications by authors named "B Leaderer"

Ambient nitrogen dioxide (NO) is derived from tailpipe vehicle emission and is linked with various of health outcomes. Personal exposure monitoring is crucial for accurate assessment of the associated disease risks. This study aimed to evaluate the utility of a wearable air pollutant sampler in determining the personal NO exposure of school children for comparison with a model-based personal exposure assessment.

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Introduction: Nitrogen dioxide (NO) is known to be a trigger for asthma exacerbation. However, little is known about the role of seasonal variation in indoor and outdoor NO levels in childhood asthma in a mixed rural-urban setting of North America.

Methods: This prospective cohort study, as a feasibility study, included 62 families with children (5-17 years) that had diagnosed persistent asthma residing in Olmsted County, Minnesota.

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Objective: Triple-crossover randomized controlled intervention trial to test whether reduced exposure to household NO or fine particles results in reduced symptoms among children with persistent asthma.

Methods: Children ( = 126) aged 5-11 years with persistent asthma living in homes with gas stoves and levels of NO 15 ppb or greater recruited in Connecticut and Massachusetts (2015-2019) participated in an intervention involving three air cleaners configured for: (1) NO reduction: particle filtration and NO scrubbing; (2) particle filtration: HEPA filter and NO scrubbing; (3) control: particle filtration and NO scrubbing. Air cleaners were randomly assigned for 5-week treatment periods using a three-arm crossover design.

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Over 4 million Americans live within 1.6 km of an unconventional oil and gas (UO&G) well, potentially placing them in the path of toxic releases. We evaluated relationships between residential proximity to UO&G wells and (1) water contamination and (2) health symptoms in an exploratory study.

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Identifying periods of increased vulnerability to air pollution during pregnancy with respect to the development of adverse birth outcomes can improve understanding of possible mechanisms of disease development and provide guidelines for protection of the child. Exposure to air pollution during pregnancy is typically based on the mother's residence at delivery, potentially resulting in exposure misclassification and biasing the estimation of critical windows of pregnancy. In this study, we determined the impact of maternal residential mobility during pregnancy on defining weekly exposure to particulate matter less than or equal to 10 μm in aerodynamic diameter (PM10) and estimating windows of susceptibility to term low birth weight.

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