Publications by authors named "B Le Ru"
Emerging evidence suggests that cancer cells may disseminate early, prior to the formation of traditional macro-metastases. However, the mechanisms underlying the seeding and transition of early disseminated cancer cells (DCCs) into metastatic tumors remain poorly understood. Through single-cell RNA sequencing, we show that early lung DCCs from esophageal squamous cell carcinoma (ESCC) exhibit a trophoblast-like 'tumor implantation' phenotype, which enhances their dissemination and supports metastatic growth.
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- The study aimed to evaluate the effectiveness of unilateral laminotomy for bilateral decompression (ULBD) in treating patients with adjacent vertebrae problems after lumbar fusion, analyzing data from 21 patients over a period from January 2021 to November 2023.
- Results were promising, showing significant improvements in pain and functional scores (like VAS, NRS, and JOA) immediately after surgery and at 12 months, along with a high satisfaction rate of 95% and no reported complications.
- The findings suggest that ULBD is a safe and effective option for managing symptomatic adjacent segment disease (ASD) in patients following lumbar fusion surgery.
Background: Although measles was declared eliminated from the United States in 2000, the frequency of measles outbreaks has increased in recent years. The ability to predict the locations of future cases could aid efforts to prevent and contain measles in the United States.
Methods: We estimated county-level measles risk using a machine learning model with 17 predictor variables, which was trained on 2014 and 2018 United States county-level measles case data and tested on data from 2019.