Publications by authors named "B Le Floch"

Background: Hepatocellular carcinoma (HCC) associated with major vasculature tumor extension is considered an advanced stage of disease to which palliative radiotherapy or chemotherapy is proposed. Surgical resection associated with chemotherapy or chemoembolization could be an opportunity to improve overall survival and recurrence-free survival in selected cases in a high-volume hepatobiliary center. Moreover, it has been 25 years since Couinaud described the entity of a posterior liver located behind an axial plane crossing the portal bifurcation.

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Background: C-reactive protein is a useful biological tool to predict infectious complications, but its predictive value in detecting organ-specific surgical site infection after liver resection has never been studied. We aimed to evaluate the predictive value of c-reactive protein and determine the cut-off values to detect postoperative liver resection-surgical site infection.

Methods: A multicentric analysis of consecutive patients with liver resection between 2018 and 2021 was performed.

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Article Synopsis
  • Graft rejection poses a significant challenge in solid-organ transplants, but understanding the low immunogenicity of liver allografts, particularly through the role of HLA-G, may enhance tolerogenic properties in other organs.
  • In a study of 118 liver transplant patients, researchers found that HLA-G plasma levels increased in the first three months post-transplant and were linked to lower rejection rates, especially when levels exceeded 50 ng/ml on day eight post-transplant.
  • There was a noted association between high HLA-G levels and lower levels of donor-specific anti-HLA antibodies, suggesting that enhancing HLA-G levels might offer new therapeutic avenues for reducing rejection in organ transplants.
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Background: The clinical general practitioner (GP) workforce is decreasing. Many studies have analysed the negative aspects of the profession but, few examine the positive aspects and job satisfaction. A European collaborative group including 8 participating countries recently conducted a qualitative study to analyse the positive factors and found 31 job satisfaction factors.

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