Publications by authors named "B Laurin"
Article Synopsis
- Glioblastoma multiforme (GBM) is the most aggressive brain tumor but rarely spreads outside the central nervous system, with only 0.4% of cases showing metastasis, possibly influenced by genetic mutations.
- A systematic review analyzed 357 studies and 211 patients, revealing that 36.9% of metastases were found near surgical sites and common metastasis locations included bone, lung, and lymph nodes.
- Unique genetic mutations were observed in primary GBM and metastatic lesions, suggesting that understanding these changes could explain how GBMs spread beyond the CNS and aid future treatment strategies.
Background: Standard of care for brain metastases involves stereotactic radiosurgery (SRS). For cases that also require surgery because of lesion size, edema, or neurological symptoms, whether to provide pre- or postoperative SRS has become a prevalent debate.
Observations: Herein, the unique case of a patient with brain metastases of the same pathology and similar size in two different brain locations at two different times is described.
Preliminary analyses revealed the presence of at least five mitochondrial clades within the widespread sea urchin Echinocardium cordatum (Spatangoida). In this study, we analyzed the genetic (two mitochondrial and two nuclear sequence loci) and morphological characteristics (20 indices) from worldwide samples of this taxon to establish the species limits, morphological diversity and differentiation. Co-occurring spatangoid species were also analyzed with mitochondrial DNA.
View Article and Find Full Text PDFA phylogenetic approach to the study of evolutionary patterns is based on taxic homologies (synapomorphies). In contrast, the recognition of evolutionary processes (namely heterochronies) involves analysis of the entire morphology. Recent developments in geometric morphometry permit analysis of morphological similarities grounded in operational homologies.
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