Publications by authors named "B Langhans"
Biliary tract cancers (BTC) are rare lethal malignancies arising along the biliary tree. Unfortunately, effective therapeutics are lacking and the prognosis remains dismal even for patients eligible for surgical resection. Therefore, novel therapeutic approaches along with early detection strategies and prognostic markers are urgently needed.
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- Primary sclerosing cholangitis (PSC) is a serious liver disease that can cause problems in bile ducts and lead to liver damage.
- This study looked at a special type of PSC where patients have high levels of a protein called IgG4 to see how it affects their health over time.
- They found that about 12.7% of patients had high IgG4 levels, and tracking these levels helps doctors understand different types of PSC better.
Introduction: Regulatory CD4 T cells (Tregs) are pivotal for inhibition of autoimmunity. Primary sclerosing cholangitis (PSC) is an autoimmune cholestatic liver disease of unknown etiology where contribution of Tregs is still unclear. Activation of the JAK-STAT pathway critically modifies functions of Tregs.
View Article and Find Full Text PDFAim: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by inflammation of the intra- and extrahepatic bile ducts. Pathogenesis of PSC is still enigmatic but is likely to be multifactorial. Recently, we identified an interleukin-6 (IL-6)-dependent signal transducer and activator of transcription 3 (STAT3) activation in CD4 TH1 and TH17 cells in PSC.
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- This study explored the relationship between type-I interferons (IFNs) and disease activity in primary sclerosing cholangitis (PSC) using both a mouse model and human serum samples.
- Elevated levels of bioactive type-I IFNs were found in both PSC patients and a specific mouse model, correlating with immune cell presence and liver enzyme levels, indicating potential severity of the disease.
- The findings suggest that particularly high concentrations of IFNω may point to a new inflammatory pathway related to PSC's progression and underlying mechanisms.