Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity.

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in adults with no curative treatment. Neurofilament (NF) level in patient' fluids have recently emerged as the prime biomarker of ALS disease progression, while NF accumulation in MNs of patients is the oldest and one of the best pathological hallmarks. However, the way NF accumulations could lead to MN degeneration remains unknown.

High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses.

Most neuronal heteromeric nicotinic receptors seem able to adopt two different stochiometries depending on the ratio of α and β subunits. In recombinant receptors these two stoichiometries have been associated with different affinities to ACh, but it is not known which stoichiometry is present at nicotinic synapses in the nervous system. One possible clue to this identification is the speed of decay of the synaptic currents.