Publications by authors named "B Lakatos"
Background: In the BUDAPEST (Biventricular Upgrade on left ventricular reverse remodeling and clinical outcomes in patients with left ventricular Dysfunction and intermittent or permanent APical/SepTal right ventricular pacing)-CRT Upgrade randomized trial, the authors have demonstrated improved mortality and morbidity after cardiac resynchronization therapy (CRT) upgrade in patients with heart failure with reduced ejection fraction (HFrEF) with high right ventricular (RV) pacing burden.
Objectives: This substudy sought to examine the impact of CRT upgrade on symptoms, functional outcome, and exercise capacity.
Methods: In the BUDAPEST-CRT Upgrade trial, 360 HFrEF patients with pacemaker or implantable cardioverter-defibrillator (ICD) and ≥20% RV pacing burden were randomly assigned (3:2) to cardiac resynchronization therapy with defibrillator (CRT-D) upgrade (n = 215) or ICD (n = 145).
(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality among people living with HIV (PLWH). The effects of antiretroviral therapy on the microbiome remain underexplored. This study aims to map the evidence of the impact of integrase strand transfer inhibitors (INSTI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) on the gut microbiota of PLWH.
View Article and Find Full Text PDFLoss of right ventricular outflow function in pulmonary hypertension.
J Heart Lung Transplant
October 2024
Article Synopsis
- The study investigates the relationship between right ventricular outflow tract (RVOT) function and the severity of pulmonary hypertension (PH) using three-dimensional echocardiography.
- Findings show that patients with PH have a significantly lower median 3D RVOT ejection fraction (EF) compared to healthy controls, indicating compromised RVOT function.
- Patients with low RVOT-EF were more likely to be in higher risk categories and experienced worse clinical outcomes, suggesting that segmental RVOT analysis can help identify high-risk individuals even if their overall right ventricular function appears normal.
Article Synopsis
- Thromboinflammation and immunothrombosis influence diseases like TTP and COVID-19, but TTP's cytokine profiles are not well-studied compared to COVID-19's cytokine storms.
- A study measured 33 soluble mediators in patients with TTP and COVID-19 to identify unique and shared features of thromboinflammation.
- The findings revealed that TTP has a more anti-inflammatory profile during acute phases with fewer immune markers, while COVID-19 shows increased pro-inflammatory markers with severity, suggesting distinct mechanisms between the two diseases.