Publications by authors named "B La Fontaine"
Multiple Sclerosis Patient Macrophages Impaired Metabolism Leads to an Altered Response to Activation Stimuli.
Neurol Neuroimmunol Neuroinflamm
November 2024
Article Synopsis
- In multiple sclerosis (MS), immune cells, particularly macrophages, play a dual role in damaging myelin and potentially aiding in its repair, but abnormalities in macrophage responses in MS patients may worsen inflammation and hinder repair processes.
- The study compared the activation of monocytes from MS patients and healthy controls, utilizing RNA sequencing and metabolomics to analyze differences in macrophage behavior and functionality.
- Findings revealed that MS macrophages preferentially activate in a proinflammatory manner, show reduced myelin processing ability, and promote the differentiation of cells toward astrocytes rather than oligodendrocytes, indicating a metabolic dysfunction and persistent inflammatory profile in MS patients.
Higher efficiency in large-scale and long-term biodiversity monitoring can be obtained through the use of Essential Biodiversity Variables, among which species population sizes provide key data for conservation programs. Relevant estimations and assessment of actual population sizes are critical for species conservation, especially in the current context of global biodiversity erosion. However, knowledge on population size varies greatly, depending on species conservation status and ranges.
View Article and Find Full Text PDFThe novel quaternary compound RbBaCrSe was synthesized and characterized in both single crystal and polycrystalline forms. Crystallizing in the monoclinic crystal system (space group 2/, cell parameters = 18.7071(4) Å, = 3.
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- * The article introduces a new method called top-down drug discovery (TD), which involves searching through a large database of fungi to find genetic locations that produce molecules targeting specific human proteins, like cyclin-dependent kinases (CDKs).
- * Researchers successfully discovered two new molecules that inhibit CDKs and improved one of them to enhance its selectivity and effectiveness, showcasing the potential of TD for developing innovative medicines.
This article presents a comprehensive study on the synthesis and structural and thermal conductivity properties of cesium-inserted chromium tellurides of formula CsCrTe. Single crystals of three different compositions ( = 0.73, 0.
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