Publications by authors named "B LAURENT"
Can democracy save children's lives? Addressing the constitutional problem of expertise.
Soc Stud Sci
January 2025
This comment critically examines Collins, Evans, and Reyes-Galindo's (CE&RG) concept of 'virtual diversity', proposed as a norm to safeguard scientific expertise in policy-making. CE&RG argue that scientists should acquire 'interactional expertise' in relevant 'non-scientific domains', enabling informed policy advice while preserving scientific integrity. This comment describes CE&RG's dualist approach, which separates epistemic and political concerns, and discusses its implications.
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- Human induced pluripotent stem cells (iPSCs) are important for studying human development and diseases, but traditional methods to obtain them can be invasive and complicated.
- This paper presents a new non-invasive method for collecting urine-derived cells (UDCs) and converting them into iPSCs using a simple and effective process.
- The study demonstrates that iPSCs derived from UDCs not only have strong differentiation potential but also highlights the method's efficiency by successfully generating cell lines from both healthy individuals and patients with Fragile X syndrome.
Providing lysophosphatidylcholine-bound omega-3 fatty acids increased eicosapentaenoic acid, but not docosahexaenoic acid, in the cortex of mice with the apolipoprotein E3 or E4 allele.
Prostaglandins Leukot Essent Fatty Acids
November 2024
Article Synopsis
- The study investigates how omega-3 fatty acids, specifically lysophosphatidylcholine (LPC) n-3, are absorbed in the brains of mice with different genetic backgrounds related to Alzheimer's risk (APOE3 vs. APOE4).
- Researchers aimed to see if supplementing LPC n-3 for two or four months would raise levels of important omega-3s (DHA and EPA) in the frontal cortex of these mice.
- Results showed that after two months, the APOE3 mice had increased EPA, but not DHA, while APOE4 mice showed no significant changes; after four months, both genotypes had increased EPA, but DHA levels remained largely unchanged, highlighting the need for more research on
Background: Oxidative stress and chronic inflammation, at both the systemic and the central level, are critical early events in atherosclerosis and Alzheimer's disease (AD).
Purpose: To investigate the oxidative stress-, inflammation-, and Tau-phosphorylation-lowering effects of pomegranate polyphenols (PPs) (punicalagin, ellagic acid, peel, and aril extracts).
Methods: We used flow cytometry to quantify the protein expression of proinflammatory cytokines (IL-1β) and anti-inflammatory mediators (IL-10) in THP-1 macrophages, as well as M1/M2 cell-specific marker (CD86 and CD163) expression in human microglia HMC3 cells.
Introduction: Adverse childhood events (ACEs) have been linked to widespread chronic pain (CP) in various cross-sectional studies, mainly in clinical populations. However, the independent role of different ACEs on the development of different types of CP remains elusive. Accordingly, we aimed to prospectively assess the associations between specific types of ACEs with the development of multisite CP in a large population-based cohort.
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