Prospective evaluation of structure-based simulations reveal their ability to predict the impact of kinase mutations on inhibitor binding.

Small molecule kinase inhibitors are critical in the modern treatment of cancers, evidenced by the existence of over 80 FDA-approved small-molecule kinase inhibitors. Unfortunately, intrinsic or acquired resistance, often causing therapy discontinuation, is frequently caused by mutations in the kinase therapeutic target. The advent of clinical tumor sequencing has opened additional opportunities for precision oncology to improve patient outcomes by pairing optimal therapies with tumor mutation profiles.

'Soft drinks are normal': understanding the lived experiences of Dutch teenagers with respect to sugar-sweetened beverages: a qualitative context-mapping study.

Background: Despite continuing efforts to reduce teenagers' consumption of sugar-sweetened beverages (SSBs), intake remains high across the globe. Currently, we lack a holistic understanding that also includes the lived experiences of teenagers in today's online and offline environments regarding the role of SSB's. The aim of the present paper is therefore twofold: (1) to gain a holistic understanding of teenagers' perspectives, beliefs, barriers, contextual triggers and latent needs (that is, their lived experiences) in relation to SSB consumption; and (2) to explore their views about which intervention strategies would be most likely to reduce their SSB consumption.

Prospective Evaluation of Structure-Based Simulations Reveal Their Ability to Predict the Impact of Kinase Mutations on Inhibitor Binding.

Small molecule kinase inhibitors are critical in the modern treatment of cancers, evidenced by the existence of over 80 FDA-approved small-molecule kinase inhibitors. Unfortunately, intrinsic or acquired resistance, often causing therapy discontinuation, is frequently caused by mutations in the kinase therapeutic target. The advent of clinical tumor sequencing has opened additional opportunities for precision oncology to improve patient outcomes by pairing optimal therapies with tumor mutation profiles.

Improving Collaboration Between Staff, Family Members, and Artists in Long-Term Dementia Care: A Participatory Action Research Project Into Health Care Clowning.

A growing amount of evidence shows the positive impact of arts-based interventions in dementia care. Existing studies focus on the impact of such interventions on individuals with dementia, yet there is little known about contextual factors influencing the impact of such practices. Contextual factors include personal and relational processes, such as the collaboration between staff, family members, and artists.

Morality in the Making: The Collaborative Relationship Between Formal Caregivers, Informal Caregivers and Nursing Home Residents.

Background And Objectives: Collaboration between formal and informal caregivers is essential for providing good care to nursing home residents. Yet, ambiguity regarding mutual roles and responsibilities often impedes effective collaboration. To address this issue, we examined how formal caregivers, informal caregivers, and residents establish a moral understanding of their responsibilities, and how these understandings affect their triadic relationship.