Publications by authors named "B L Urquhart"
Article Synopsis
- - The study aimed to assess the death risk in older adults taking low-dose methotrexate when also prescribed TMP-SMX compared to a cephalosporin.
- - Researchers matched 1,602 adults on each antibiotic to analyze the 30-day outcomes, finding similar death rates but increased risks of hospitalization and infection with TMP-SMX.
- - The conclusion indicated no higher death risk from TMP-SMX, but it was linked to increased hospitalization rates, suggesting that the benefits of this co-prescription need careful consideration.
Importance: Trimethoprim-sulfamethoxazole (TMP-SMX) may increase digoxin concentration, a medication with a narrow therapeutic index. Small changes in digoxin concentration could predispose individuals to the risk of toxicity.
Objective: To characterize the risk of digoxin toxicity in older adults taking digoxin following co-prescription of TMP-SMX compared with co-prescription of amoxicillin.
Article Synopsis
- Annexin A5 is a protein that helps reduce inflammation, prevent blood clotting, and avoid cell death, showing promise in improving organ function in sepsis models.
- A clinical trial tested a recombinant version of annexin A5 (SY-005) for severe COVID-19, with patients receiving low (50 μg/kg) or high (100 μg/kg) doses or placebo over 7 days.
- Results indicated that SY-005 was quickly cleared from the body without significant changes in blood coagulation or kidney function, suggesting it was safe and well-tolerated in the participants.
Pharmacometabolomics in Drug Disposition, Toxicity, and Precision Medicine.
Drug Metab Dispos
October 2024
The precision medicine initiative has driven a substantial change in the way scientists and health care practitioners think about diagnosing and treating disease. While it has long been recognized that drug response is determined by the intersection of genetic, environmental, and disease factors, improvements in technology have afforded precision medicine guided dosing of drugs to improve efficacy and reduce toxicity. Pharmacometabolomics aims to evaluate small molecule metabolites in plasma and/or urine to help evaluate mechanisms that predict and/or reflect drug efficacy and toxicity.
View Article and Find Full Text PDFImportance: Low-dose methotrexate is used to treat rheumatoid arthritis and psoriasis. Due to its kidney elimination, better evidence is needed to inform its safety in adults with chronic kidney disease (CKD).
Objectives: To compare the 90-day risk of serious adverse events among adults with CKD who started low-dose methotrexate vs those who started hydroxychloroquine and to compare the risk of serious adverse events among adults with CKD starting 2 distinct doses of methotrexate vs those starting hydroxychloroquine.