Demonstration of Tunable Control over a Delayed-Release Vaccine Using Atomic Layer Deposition.

Many vaccines require multiple doses for full efficacy, posing a barrier for patient adherence and protection. One solution to achieve full vaccination may be attained with single-administration vaccines containing multiple controlled release doses. In this study, delayed-release vaccines were generated using atomic layer deposition (ALD) to coat antigen-containing powders with alumina.

High-Capacity Cardiac Signal Acquisition System for Flexible, Simultaneous, Multidomain Acquisition.

Capturing cardiac electrical propagation or electrocardiographic images demands simultaneous, multidomain recordings of electrocardiographic signals with adequate spatial and temporal resolution. Available systems can be cost-prohibitive or lack the necessary flexibility to capture signals from the heart and torso. We have designed and constructed a system that leverages affordable commercial products (Intantech, CA, USA) to create a complete, cardiac signal acquisition system that includes a flexible front end, analog signal conditioning, and defibrillation protection.

Carbon dioxide-based facile synthesis of cyclic carbamates from amino alcohols.

We report herein a straightforward general method for the synthesis of cyclic carbamates from amino alcohols and carbon dioxide in the presence of an external base and a hydroxyl group activating reagent. Utilizing p-toluenesulfonyl chloride (TsCl), the reaction proceeds under mild conditions, and the approach is fully applicable to the preparation of various high value-added 5- and 6-membered rings as well as bicyclic fused ring carbamates. DFT calculations and experimental results indicate a S2-type reaction mechanism with high regio-, chemo-, and stereoselectivity.