Publications by authors named "B L Shwetha"
Article Synopsis
- This study focuses on validating beam data from three beam-matched linear accelerators (LAs) for accurate radiation delivery in fractionated stereotactic treatment, comparing measured data to vendor reference data.
- Measurements included percentage depth dose, beam profiles, output factors, and dynamic multi-leaf collimator factors for different photon types, achieving high accuracy with gamma analysis above 97%.
- Quality assurance for eighty patient-specific plans showed median passing rates of over 76% to 98% across various gamma criteria, indicating compatibility of treatment across the beam-matched LAs without the need for re-planning.
Aim: This study aims to validate the Razor Nano Chamber (RNC) and Razor Chamber (RC) dosimetric characteristics in a small field. The dosimetric parameters of the two chambers were compared.
Materials And Methods: The chamber characteristics of leakage (pre and post), stability, energy dependency, dose linearity, dose rate effect, stem effect, angular dependency, ion recombination effect, and polarity effect were studied.
The vital role played by microtubules in the cell division process, marks them as a potential druggable target to decimate cancer. A novel furan-2-carboxamide based small molecule, is a selective microtubule stabilizing agent (MSA) with IC ranging from 4 µM to 8 µM in different cancer cell lines. Inhibition of tubulin polymerization or stabilization of tubulin polymers abrogates chromosomal segregation during cell division, results in cell cycle arrest and leads to cell death due to the delayed repair mechanism.
View Article and Find Full Text PDFArticle Synopsis
- Several microtubule targeting agents (MTAs) have shown effectiveness as anticancer drugs, but resistance often limits their use, creating a need for new therapies.
- Researchers discovered a novel MTA, CPPF, which effectively suppresses cancer cell proliferation, including in multidrug-resistant lines that do not respond to conventional MTAs.
- CPPF works by depolymerizing microtubules, causing mitotic arrest and apoptosis, and has demonstrated low toxicity in zebrafish models, indicating its potential as a successful new anticancer treatment.
Background: Increased enthusiasm toward newer fashion trends among rural India along with the lack of government regulation has led to increased tattoo reactions.
Objective: The objective of this study is to describe various clinical manifestations of hypersensitive reactions to tattoo ink reported at a tertiary care hospital in Mandya district.
Materials And Methods: An observational study was carried out over a period of 1 year from June 2014 to May 2015 at Mandya Institute of Medical Sciences, Mandya.