Plant Cell Culture-Derived Saponin Adjuvant Enhances Immune Response Against a Stabilized Human Metapneumovirus Pre-Fusion Vaccine Candidate.

Unlabelled: Human metapneumovirus (HMPV) is a significant respiratory pathogen, particularly in vulnerable populations.

Background: No vaccine for the prevention of HMPV is currently licensed, although several subunit vaccines are in development. Saponin-based adjuvant systems (AS), including QS-21, have transformed the field of subunit vaccines by dramatically increasing their potency and efficacy, leading to the development of several licensed vaccines.

Broadening and amplifying the effects of positive psychology courses on college student well-being, mental health, and physical health.

: In this study, we evaluated the effects of a semester-long, multi-component positive psychology course on undergraduate well-being, mental health, and physical health. : Using a quantitative, quasi-experimental, pretest-posttest design, participants in the positive psychology course ( = 38) were compared to a control condition ( = 41) on measures of well-being, physical health, and mental health. The positive psychology course included traditional lectures, experiential homework, small group labs, and individual consultations.

Virtual surgical planning in microsurgical head and neck reconstruction: The Newcastle experience.

Head and neck microvascular reconstruction is a complex but powerful tool following immediate cancer ablation or delayed sequalae after cancer treatment. Virtual surgical planning (VSP), using computer-aided design or computer-aided manufacturing has emerged as a potentially beneficial adjunct to head and neck reconstruction. The aim of this study was to assess the outcomes of VSP technology using the KLS Martin custom-made cutting guides and low-profile plates in head and neck microvascular reconstruction in our centre.

Addiction Medicine: Opioid Use Disorder.

Most overdose deaths in the United States involve opioids. Identification and management of opioid use disorder by primary care physicians is a critical need in health care. Substance use disorders share neurobiological dysregulation of the central motivation and reward pathway (powered by dopamine) that manifests as a cycle of addiction driven by impulse and compulsion.

Addiction Medicine: Tobacco Use Disorder.

The number one cause of preventable disease, disability, and death in the United States is tobacco use. According to data from the National Health Interview Survey, 18.7% of US adults (46 million people) currently use a tobacco product.