Implementation of an adherence pharmacy referral protocol for patients taking sacubitril/valsartan.

Background: Heart failure is a prevalent disease state associated with limitations in function, hospitalization, and death. The 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America guidelines recommend medications including sacubitril/valsartan to decrease morbidity and mortality in patients with heart failure. However, if patients are nonadherent to treatment or experience barriers to care, they will forgo these benefits.

Considerations for Social Networks and Health Data Sharing: An Overview.

The use of network analysis as a tool has increased exponentially as more clinical researchers see the benefits of network data for modeling of infectious disease transmission or translational activities in a variety of areas, including patient-caregiving teams, provider networks, patient-support networks, and adoption of health behaviors or treatments, to name a few. Yet, relational data such as network data carry a higher risk of deductive disclosure. Cases of reidentification have occurred and this is expected to become more common as computational ability increases.

Larger reductions in blood pressure during post-exercise standing, but not middle cerebral artery blood velocity, in resistance-trained versus untrained individuals.

Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure, with hypotension and cerebral hypoperfusion commonly observed immediately following RE. Whether the cerebral vasculature adapts to these regular blood pressure challenges is unclear. This study examined the cerebrovascular response to post-dynamic RE orthostasis.

Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation.

Background: Overweight and obesity are highly prevalent in people with severe mental illness (SMI). Antipsychotic-induced weight gain (AIWG) is one of the most commonly reported and distressing side effects of treatment and people living with SMI place a high value on the avoidance of this side effect. Metformin is the most effective pharmacological intervention studied for the prevention of AIWG yet clear guidelines are lacking and evidence has not translated into practice.

Dysphagia is a risk factor of malnutrition in X-linked Dystonia-Parkinsonism.

Introduction: Malnutrition is a leading cause of death for persons living with X-linked dystonia-parkinsonism (XDP), a degenerative disease endemic to the Philippines. Difficulty swallowing has been linked to malnutrition in other populations; however, knowledge of this relationship is limited in XDP. As such, the purpose of this study was to determine the association between dysphagia and malnutrition in this population.