The A to Z of Peroral Endoscopic Myotomy.

Peroral endoscopic myotomy (POEM) is a novel technique within the field of third space endoscopy. The overarching principal is creation of a mucosal incision, careful dissection of the submucosal space using an electrosurgical knife to reach the muscularis (ie, tunneling), performing a controlled myotomy, and finally, closure of the mucosal incision. POEM was first developed for the management of achalasia, and now a decade of evidence shows the procedure is safe, effective, and highly reproducible.

Hemostatic powder TC-325 as first-line treatment option for malignant gastrointestinal bleeding: a cost-utility analysis in the United Kingdom.

Background: Randomized controlled trials have shown that hemostatic powder (TC-325) results in greater immediate hemostasis and lower 30-day rebleeding rates than standard endoscopic therapy (SET) for management of malignant upper gastrointestinal bleeding (MUGIB). We explored whether TC-325 would be a cost-effective first-line option for patients with MUGIB compared with SET in the United Kingdom.

Methods: A decision tree was developed for patients with MUGIB, assessing initial therapy with TC-325 or SET over a 30-day period.

Assessing thermal performance: Dataset from an experimental study on U-value variability.

In order to achieve energy savings in existing buildings, there is an increasing need for energy audits and performance checks. In this regard, estimating a building's U-value is crucial, and there are a variety of methods available for achieving this. Heat flow meters can be used to measure U-value in situ.