Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study.

Tamoxifen is an estrogen-receptor (ER) antagonist, used as adjuvant treatment of ER-positive breast cancer. It is converted by CYP2D6 into endoxifen, its most active metabolite. Patients with endoxifen plasma concentrations <16 nM face a higher risk of recurrence.

[Barriers for including sufficient participants in multi-center drug research].

Background: The SPACe 2: STAR trial is a multicenter trial in children with an autism spectrum disorder, divided over nine centers in the Netherlands. However, it is challenging to include enough participants due to various factors, including the varying status of the disorder and willingness of parents and children.

Aim: To identify and overcome the bottlenecks for practitioners during the trial to prevent major delays.

Predicting sepsis mortality into an era of pandrug-resistant E. coli through modeling.

Background: Infections caused by antibiotic-resistant bacteria are increasingly frequent, burdening healthcare systems worldwide. As pathogens acquire resistance to all known antibiotics - i.e.

Confronting the "Weaponization" of Genetics by Racists Online and Elsewhere.

Genomics research is regularly appropriated in social and political contexts to publicly legitimize unjust and malicious political views, policies, and actions. In recent years, there have been high-profile cases of mass shooters, public intellectuals, and political insiders using genomics findings to convince audiences that deadly force and coercive policies against racial minorities are warranted. To create a just genomics, geneticists must consider what makes their research so attractive and adaptable for the legitimization of unjust ends and what they can do to counter such appropriations.