Publications by authors named "B L Kee"
Appendiceal Adenocarcinoma (AA) is a rare gastrointestinal cancer with no FDA-approved targeted therapies. Here, we retrospectively compare BRAF-mutant AA and colorectal cancer (CRC). BRAF mutation is rare in AA (3%).
View Article and Find Full Text PDFPurpose: Appendiceal adenocarcinoma is a rare malignancy with distinct histopathologic subtypes and a natural history with metastasis primarily limited to the peritoneum. Little is known about the molecular pathogenesis of appendiceal adenocarcinoma relative to common tumors.
Experimental Design: We analyzed molecular data for patients within the Guardant Health database with appendix cancer (n = 718).
Article Synopsis
- The study investigates the prevalence of the HLA-B*58:01 allele, which is linked to severe skin reactions from allopurinol, among gout patients in Malaysia's multiethnic population.
- A total of 547 patients from Malay, Chinese, and Indian backgrounds were tested, revealing an overall allele prevalence of 16.8%, with the highest at 21.8% in Chinese patients.
- Notably, despite having the HLA-B*58:01 allele, none of the patients who used allopurinol developed severe cutaneous reactions, indicating the need for a better predictive model for these reactions.
Bacterial small RNAs (sRNAs) play crucial roles in coordinating gene regulatory networks in various physiological processes, including biofilm formation. In this study, RNA sequencing was performed on biofilm ( = 4) and planktonic ( = 4) cells harvested at 10 h (pre-stationary phase of biofilm development) to identify biofilm-associated sRNAs in human methicillin-susceptible (MSSA) recovered from urine isolate. A total of 56 highly expressed sRNAs were identified with 15 overlapping sRNA genes (srn_9348, sprD, sRNA205, sRNA288, srn_2467, Sau-25, srn_2468, sRNA260, sRNA200, RsaE, sRNA397, Teg55, Teg60, RsaX05 and Teg140).
View Article and Find Full Text PDFImportance: Disparity in overall survival (OS) and differences in the frequency of driver gene variants by race and ethnicity have been separately observed in patients with colorectal cancer; however, how these differences contribute to survival disparity is unknown.
Objective: To quantify the association of molecular, socioeconomic, and clinical covariates with racial and ethnic disparities in overall survival among patients with colorectal cancer.
Design, Setting, And Participants: This single-center cohort study was conducted at a tertiary-level cancer center using relevant data on all patients diagnosed with colorectal cancer from January 1, 1973, to March 1, 2023.