Publications by authors named "B L Kasten"
Purpose: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has continually increased during the past several decades. Using transoral robotic surgery (TORS) significantly improves functional outcomes relative to open surgery for OPSCC. However, TORS limits tactile feedback, which is often the most important element of cancer surgery.
View Article and Find Full Text PDFWhile surgical guides have allowed for more highly accurate immediate implant placement in the esthetic zone, only a few techniques have been described to predictably position an immediate implant provisional. Even fewer techniques have addressed repositioning a patient's extracted tooth for use as the interim implant restoration. This article describes a workflow for the fabrication of a dual-purpose surgical guide that allows for guidance of implant placement as well as repositioning of a decoronated tooth that will serve as a provisional.
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- Axial pattern flaps are frequently used to reconstruct areas after the removal of soft tissue tumors, and this study looks at how these flaps rely on the blood supply from the underlying wound bed.
- Researchers conducted experiments on mice divided into five groups with varying silicone applications to isolate the effects on the flap’s viability.
- Results showed that while most groups had similar flap viability compared to a control, the group with silicone covering the entire wound bed and sacrificing the blood supply had a notable decrease in viability, indicating that the wound bed vasculature isn't crucial for the early survival of the flap.
Determination of treatment response to immunotherapy in glioblastoma multiforme (GBM) is a process which can take months. Detection of CD8 T cell recruitment to the tumor with a noninvasive imaging modality such as positron emission tomography (PET) may allow for tumor characterization and early evaluation of therapeutic response to immunotherapy. In this study, we utilized Zr-labeled anti-CD8 cys-diabody-PET to provide proof-of-concept to detect CD8 T cell immune response to oncolytic herpes simplex virus (oHSV) M002 immunotherapy in a syngeneic GBM model.
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