Publications by authors named "B L Geller"
VISTA is a key immune checkpoint receptor under investigation for cancer immunotherapy; however, its signaling mechanisms remain unclear. Here we identify a conserved four amino acid (NPGF) intracellular motif in VISTA that suppresses cell proliferation by constraining cell-intrinsic growth receptor signaling. The NPGF motif binds to the adapter protein NUMB and recruits Rab11 endosomal recycling machinery.
View Article and Find Full Text PDFThe short-chain fatty acids (SCFAs) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. To better understand the function of these modifications, we used chromatin immunoprecipitation followed by sequencing to map the genome-wide location of four short-chain acyl histone marks, H3K18pr, H3K18bu, H4K12pr and H4K12bu, in treated and untreated colorectal cancer (CRC) and normal cells as well as in mouse intestines in vivo. We correlate these marks with open chromatin regions and gene expression to access the function of the target regions.
View Article and Find Full Text PDFPurpose: Pre-treatment [Tc]TcMAA-based radioembolization treatment planning using multicompartment dosimetry involves the definition of the tumor and normal tissue compartments and calculation of the prescribed absorbed doses. The aim was to compare the real-world utility of anatomic and [Tc]TcMAA-based segmentation of tumor and normal tissue compartments.
Materials And Methods: Included patients had HCC treated by glass [Y]yttrium microspheres, ≥ 1 tumor, ≥ 3 cm diameter and [Tc]TcMAA SPECT/CT imaging before treatment.
Article Synopsis
- Arterial hyperoxia (high levels of oxygen in the blood) is linked to worse outcomes in critically ill patients, but its effects in cardiac intensive care units (CICUs) have not been previously studied.
- A study of over 3,300 patients showed a J-shaped relationship between oxygen levels at admission and in-hospital mortality, with a significant increase in risk for those with PaO2 levels over 300 mmHg.
- The findings suggest that higher oxygen levels upon admission to the CICU are associated with increased mortality, particularly for patients with severely elevated PaO2 levels.
Article Synopsis
- Sarcopenia, a condition characterized by loss of muscle mass, is prevalent in patients with cirrhosis and contributes to increased mortality, particularly in those undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedures.
- In a study of 232 cirrhotic patients who received TIPS, researchers found that 41.38% were diagnosed with sarcopenia, which negatively impacted survival rates compared to those without sarcopenia.
- The analysis revealed that sarcopenia is an independent risk factor for a higher chance of death within one year after TIPS, indicating its importance in pre-procedure assessments.