Micro-concentrators for a microsystems-enabled photovoltaic system.

A 100X magnification, ± 2.5° field of view micro-concentrating optical system has been developed for a microsystems-enabled photovoltaic (MEPV) prototype module using 250 µm diameter multi-junction "stacked" PV cells.

The monkey safety test for neurovirulence of yellow fever vaccines: the utility of quantitative clinical evaluation and histological examination.

Two different derivatives of the 17D strain of yellow fever (YF) vaccine virus, i.e. ALV-free seed virus 6676 and three consecutive vaccine lots, A, B and C, obtained from another seed, were compared in monkey neurovirulence tests using rhesus and cynomolgus monkeys.

Rhesus diploid rabies vaccine (adsorbed): neurological safety in guinea pigs and Lewis rats.

Rabies vaccine produced in rhesus diploid cells (RDRV) and adsorbed on aluminium phosphate was evaluated for its neurological safety in guinea pigs and Lewis rats. The vaccine (as well as aluminium phosphate itself) in combination with myelin basic protein did not induce experimental allergic encephalomyelitis (EAE) when injected into either species. RDRV combined with complete Freund's adjuvant still failed to induce any signs of EAE.

Sensitization induced in guinea pigs with beta-propiolactone-treated serum albumin: experimental evidence for the cause of allergic reactions in humans receiving human diploid cell rabies vaccines.

beta-Propiolactone-treated (BPL-T) homologous serum albumin caused anaphylaxis in guinea pigs with a frequency and severity equal to that of guinea pigs inoculated with human albumin. Untreated guinea pig serum albumin did not cause any reactions in these animals. Some recipients of current rabies vaccine produced in human diploid cells available in the USA develop systemic allergic reactions, usually following booster immunization.

Tumorigenicity testing of primate cell lines in nude mice, muscle organ culture and for colony formation in soft agarose.

Primate neoplastic and finite cell lines were tested in one in vivo and two in vitro test systems: adult nude mice, muscle organ culture (MOC) and soft agarose (SA). Comparison of the sensitivity of the systems indicated that nude mice were inferior to either in vitro system: WI-38 VA13 (an SV40 transformed cell line) did not cause tumours in these animals yet it behaved as if it were neoplastic in MOC and formed colonies in SA. There was complete correlation between results obtained in MOC and SA.