Publications by authors named "B L Blake"
The pharmacokinetics of Δ-tetrahydrocannabinol (Δ-THC) has not been established in ruminants. Pharmacokinetic knowledge is important given feeding industrial hemp biomass has been shown to result in tissue residues post feeding in sheep. Due to a lack of testing and available data, a 'maximum' concentration of Δ-THC has not been currently set for foods of animal origin.
View Article and Find Full Text PDFGlobal Progression Rates of Precursor Lesions for Gastric Cancer: A Systematic Review and Meta-Analysis.
Clin Gastroenterol Hepatol
October 2024
Background & Aims: Whether gastric cancer (GC) precursor lesions progress to invasive cancer at similar rates globally remains unknown. We conducted a systematic review and meta-analysis to determine the progression of precursor lesions to GC in countries with low versus medium/high incidence.
Methods: We searched relevant databases for studies reporting the progression of endoscopically confirmed precursor lesions to GC.
Patients with myotonia congenita suffer from slowed relaxation of muscle (myotonia), due to hyperexcitability caused by loss-of-function mutations in the ClC-1 chloride channel. A recent study suggested that block of large-conductance voltage- and Ca- activated K channels (BK) may be effective as therapy. The mechanism underlying efficacy was suggested to be lessening of the depolarizing effect of build-up of K in t-tubules of muscle during repetitive firing.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to understand the global prevalence of precursor lesions for gastric cancer (GC), focusing on conditions like atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia across different regions with varying GC risks.
- - The analysis of 166 qualifying studies found that the global prevalence rates were 25.4% for AG, 16.2% for IM, and 2.0% for dysplasia, with higher rates in countries with medium and high GC incidence, especially among those infected with Helicobacter pylori.
- - The findings indicate that a significant number of individuals with precursor lesions may not show symptoms, highlighting that symptomatic evaluation alone might not effectively identify those at risk for GC,
Standardizing Extracted Data Using Automated Application of Controlled Vocabularies.
Environ Health Perspect
February 2024
Background: Extraction of toxicological end points from primary sources is a central component of systematic reviews and human health risk assessments. To ensure optimal use of these data, consistent language should be used for end point descriptions. However, primary source language describing treatment-related end points can vary greatly, resulting in large labor efforts to manually standardize extractions before data are fit for use.
View Article and Find Full Text PDF