Publications by authors named "B L Bergman"
Introduction: Celebrate Recovery (CR) is a new, rapidly growing mutual-help organization (MHO) based on Christian principles and is the largest religious MHO in the US. However, very little is known about CR empirically.
Methods: Secondary data analysis of the National Recovery Study (NRS) (Kelly et al.
Objective: Circulating lipids are linked with insulin resistance and increased cardiovascular disease risk. We previously reported that dihydroceramides, a specific type of sphingolipid, are elevated in insulin-resistant individuals; however, little is known regarding whether insulin-sensitizing lifestyle interventions can improve profiles of sphingolipids and other lipid species.
Methods: A total of 21 individuals with obesity participated in a 3-month lifestyle intervention of combined weight loss and exercise training.
Article Synopsis
- Peripancreatic adipose tissue (PAT), which accumulates with obesity, negatively affects metabolic health and beta cell function, highlighting its significance compared to subcutaneous adipose tissue (SAT).
- PAT secretes higher levels of inflammatory substances and certain adipokines linked to poor metabolic outcomes, with variations in islet insulin secretion observed between male and female donors.
- RNA sequencing reveals that PAT influences gene transcription and lipid metabolism in islets in a sex-dependent manner, suggesting different metabolic impacts compared to SAT.
Article Synopsis
- Intracellular accumulation of ceramide in muscle cells may be a key factor in insulin resistance linked to type 2 diabetes, particularly influenced by oxidised phosphatidylcholine found in oxidised LDL.
- A study involving 58 individuals showed that higher levels of oxidised phosphatidylcholine are associated with decreased insulin sensitivity and increased ceramide levels in skeletal muscle.
- Experiments on rat muscle cells revealed that specific oxidised phosphatidylcholine species, like POVPC, promote ceramide accumulation, trigger inflammation, and contribute to insulin resistance.
Article Synopsis
- The study aimed to explore how mesenchymal stem cell (MSC) lipid metabolism and maternal factors, aside from body mass, might impact the risk of obesity in children.
- Researchers analyzed MSCs from infants of mothers with obesity or normal weight, using techniques like lipidomics and measuring various metabolic indicators during pregnancy.
- Findings revealed distinct MSC clusters linked to maternal metabolic health, suggesting that these clusters could potentially forecast child obesity at a young age, although further validation is needed.