Publications by authors named "B Kuruvilla"
The following are clinical consensus statements (CCS) on the topic of hallux rigidus sponsored by the American College of Foot and Ankle Surgeons. A core panel synthesized the data and divided the topic in to twelve sections, each section contained a variable number of consensus statements, based upon complexity. Overall there were 24 consensus statements synthesized for this subject matter.
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- - Rhuleave-K™ is a blend of Curcuma longa extract, Boswellia serrata extract, and black sesame seed oil, whose safety was tested through acute and sub-chronic toxicity studies on rats.
- - In the acute study, rats were given a maximum dose of 2000 mg/kg, with no signs of toxicity or mortality observed, leading to an LD50 greater than 2000 mg/kg.
- - During the 90-day sub-chronic study at doses of 100, 500, and 1000 mg/kg/day, no toxic effects were observed; the NOAEL (No Observed Adverse Effect Level) was established at 1000 mg/kg daily.
Effective chemoprevention is critical for improving outcomes of oral cancer. As single agents, curcumin and metformin are reported to exhibit chemopreventive properties, in vitro as well as in patients with oral cancer. In this study, the chemopreventive efficacy of this drug combination was tested in a 4-nitro quinoline-1-oxide (4NQO) induced mice oral carcinogenesis model.
View Article and Find Full Text PDFCurcumin, the active component present in Curcuma longa of the family Zingiberaceae, has a number of pharmacological effects, including potential anti‑inflammatory activity. One of the major limitations of curcumin/turmeric extract is its poor absorption through the gastrointestinal tract. Several approaches have been adopted to increase the bioavailability of curcumin, including loading curcumin into liposomes or nanoparticles, complexation with phospholipids, addition of essential oils and synthesizing structural analogues of curcumin.
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