Blood-retina barrier permeability and its relation to the progression of diabetic retinopathy in type 1 diabetics. An 8-year follow-up study.

Blood-retina barrier (BRB) permeability and its relation to the progression of diabetic retinopathy was studied over an 8-year period in 50 insulin-dependent diabetic patients. Initially, the patients underwent an ophthalmological examination, including measurement of best corrected visual acuity, fundus photography and vitreous fluorometry for determination of BRB permeability. After 8 years the patients were reexamined and their retinal status and clinical course were evaluated.

Clinical course and prognosis of pseudotumor cerebri. A prospective study of 24 patients.

In a prospective study, 24 consecutive patients with pseudotumor cerebri were followed for an average of 49 months with regular neurologic and ophthalmologic examinations. At the first examination the intracranial pressure was between 18 and 45 mm Hg; several patients had pressure waves up to 70 mm Hg and decreased conductance to cerebrospinal fluid outflow. In the majority, medical treatment, usually with diuretics and acetazolamide, induced a rapid relief of symptoms, but about 25% had a more protracted disease course with persistent headache, asthenia and memory disturbances interfering with daily life.

Blood-retinal barrier permeability versus diabetes duration and retinal morphology in insulin dependent diabetic patients.

The blood-retinal barrier permeability to fluorescein was quantitated in 54 patients (22 females and 32 males) with insulin dependent diabetes mellitus (IDDM) of different duration. Correlation was demonstrated between permeability and diabetes duration. A normal permeability was measured in patients with up to ten years diabetes duration.

Breakdown of the blood-retinal barrier in multiple sclerosis measured by vitreous fluorophotometry.

Periphlebitis retinae in multiple sclerosis appears as transitory cellular infiltrations around veins in an otherwise normal retina. Similar cellular infiltrations have been found around veins in the central nervous system. In the present study the blood-retinal barrier has been investigated by vitreous fluorophotometry.

The blood-retinal barrier permeability to fluorescein in normal subjects and in juvenile diabetics without retinopathy.

The blood-retinal barrier permeability to fluorescein was determined in 20 eyes from 17 normal volunteers (mean age 31 years) and in 20 eyes from 19 juvenile diabetics without apparent retinopathy (mean age 35 years - mean duration of diabetes 6 years). The permeability was in normal subjects (1.1 +/- 0.